This recorded case presents the treatment of an 81-year-old woman admitted with a severe wake-up stroke. She presented with aphasia, facial asymmetry and left hemiplegia, corresponding to an NIHSS score of 26. MRI demonstrated early ischaemic changes with a significant diffusion-FLAIR mismatch and a large ischaemic penumbra. The patient received intravenous tenecteplase at the referring stroke centre before transfer for endovascular treatment.
This case enhances several important considerations in the management of tandem occlusion stroke, from patient selection and transfer logistics to revascularisation strategy and post-procedural decision-making: