What if the absence of a “last known well” no longer meant the end of treatment options?
In this case, Wim H. van Zwam from Maastricht, The Netherlands, along with Daniel Vela-Duarte from West Palm Beach, USA, tackle the profound dilemma of managing wake-up strokes, where the exact time of onset is unknown. Conventional protocols hinge on “last known well,” but this presentation challenges that paradigm. Explore how they reimagine treatment eligibility, present compelling clinical evidence, and advocate for more inclusive stroke care, pushing boundaries toward faster, smarter interventions.