Markus Möhlenbruch explores recanalization techniques for large vessel occlusions (LVOs) versus medium vessel occlusions (MeVOs) at LINNC Paris 2024. While initial registry data shows no significant differences in primary outcomes, recanalization rates, or overall safety profiles, differences emerge when excluding M2 occlusions: MeVO patients typically present with lower baseline NIHSS and higher ASPECTs compared to LVO patients. However, MeVO thrombectomy procedures entail a higher risk of hemorrhagic complications such as perforation and sulcal subarachnoid hemorrhage. Markus Möhlenbruch underscores the need to tailor device adaptations and treatment strategies, pending the results of ongoing randomized controlled trials to establish definitive treatment guidelines.