Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke

OBJECTIVES	To establish the effectiveness and safety of intraarterial mechanical thrombectomy in patients with large baseline infarcts of the anterior circulation.
STUDY	Investigator-designed and -initiated, pragmatic, phase III, prospective, randomized, open-label, blinded endpoint, multicenter trial with adaptive enrichment design.
POPULATION	Patients from 19 to 85 years of age presenting with acute ischemic stroke due to occlusion of the internal carotid artery terminus or middle cerebral artery M1 segment within 24 hours of symptoms onset, with NIHSS score ≥6, evidence of a large baseline infarct as ASPECTS 2-5 on NCCT, and pre-stroke mRS score 0 to 1.
ENDPOINTS	The primary efficacy endpoint was the 90-day utility-weighted modified Rankin Scale (mRS) score, the 90-day death rate as a primary safety endpoint, and several secondary endpoints, including NIHSS at 24 hours (16–36 hours) from randomization, NIHSS at 6±1 days or discharge, length of hospital stay, among others.

Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke - TESLA