Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials

OBJECTIVES	Highly Effective Reperfusion evaluated in Multiple Endovascular Stroke Trials (HERMES) collaboration was created to pool patient-level data from five trials (MR CLEAN, ESCAPE,REVASCAT, SWIFT PRIME, and EXTEND IA) with the aim of addressing the remaining questions about whether thrombectomy after large-vessel ischemic stroke is efficacious across the diverse populations included.
STUDY	Meta-analysis of individual patient data from five randomized trials: MR CLEAN, ESCAPE,REVASCAT, SWIFT PRIME, and EXTEND IA.
POPULATION	Between December 2010, and December 2014, patients with acute ischemic stroke caused by occlusion of the proximal anterior artery circulation were randomly assigned to receive either endovascular thrombectomy within 12h of symptom onset or standard care (control).
METHODS	Mixed-effects ordinal logistic regression models to calculate common odds ratios (cOR) for the primary outcome in the whole population (shift analysis) and in subgroups after adjustment for age, sex, baseline stroke severity (National Institutes of Health Stroke Scale score), site of occlusion (internal carotid artery vs M1 segment of middle cerebral artery vs M2 segment of middle cerebral artery), intravenous alteplase (yes vs no), baseline Alberta Stroke Program Early CT score, and time from stroke onset to randomization.
ENDPOINTS	Calculate reduced disability on the modified Rankin Scale (mRS) at 90 days in the pooled population; to examine heterogeneity of EVT effect across prespecified subgroups.

Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials - HERMES collaboration meta-analysis

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