Literature Review

Time for a Time Window Extension: Insights from Late Presenters in the ESCAPE Trial

Pakrit Jittapiromsak

Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke (ESCAPE) trial was published in 2015 and showed good clinical results in the endovascular arm.
This trial enrolled patients up to 12 hours after symptom onset (n=315). However, the benefit in the extended time window was not clearly proven.

This study is a subgroup analysis of late presenters including 59 patients (randomized 5.5-12 hr, expected to be treated after 6 hr). There was no difference in treatment effect between early and late presenters. The results showed favourable clinical outcome in the endovascular arm (mRS 0-2 at 90 days 48.5% vs. 29.2%, p 0.18): more asymptomatic intracerebral hemorrhage was observed, with no difference in symptomatic hemorrhage.


Join now the LINNC online community!

Not registered yet? Create your 100% free LINNC online account in less than 1 minute and enjoy a full range of educational content: LIVE & recorded cases from LINNC Courses and Seminars, expert interviews, cases shared by worldwide experts, latest news from Interventional neuroradiology field and much more!

LINNC online is also an interactive platform on which you can join your peers, share comments, live chat during LINNC Masterclass or answer polls.

You already have an account:

Create your account:

Your free LINNC account will offer you access to:
  • A full library of LIVE cases from LINNC Course
  • LINNC Masterclass Replays & Lives
  • Cases commented by experts on various topics
  • Recorded Cases commented during the LINNC Course and Seminars
  • And much more…