In vitro model of calcified cerebral emboli

Pr Frédéric Clarençon

Pr. Frédéric Clarençon
Head of the Department of Interventional Neuroradiology
Pitié Salpêtrière Hospital
Paris, France



Calcified cerebral emboli (CCE) are a rare cause of acute ischemic stroke, frequently associated with very low recanalization rates and poor outcomes.

With the support of the Neuro Thromboembolic Initiative ressources , authors were able to develop appropriate calcified replicates in an M1 in silico occlusion model.

silico occlusion model

Figure 1



Four different endovascular approaches were evaluated (6 attempts):

  • Contact Apsiration (CA)
  • Stent Retriever Alone (SR)
  • Combined technique without Balloon guide catheter (BGC)
  • Combined technique with Balloon guide catheter



BGC+Dual asp.

No flow arrest


CCE were characterized here and appeared considerably stiffer than thrombus.

Combined technique associated with proximal flow control was associated with better but unsatisfactory results.

The successful development of such a CCE model should allow the evaluation of further solutions.


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