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Leave No ELVO Behind for sure! But what does come ‘round? Anesthesia, Blood pressure, Neuroprotection and more…

Last update on May 23, 2019

Friday saw the coming to an end of the 5th European Stroke Organization Conference (ESOC). Besides offering top-level scientific content, what made this year’s meeting so brilliant was the fact that it brought together the Neurology, Interventional Neuroradiology, Neuroradiology and Neurosurgery communities – all gathered here in Milan with the single purpose of improving Stroke care!

ESOC numbers

 

From the point-of-view of an endovascular surgeon, there were many lectures that could be highlighted. The morning scientific session, for instance, saw a variety of key points concerning peri-procedural management:

GA versus CS/LA
General anesthesia, Conscious sedation… or local anesthesia?

From a pooled-analysis of GA versus CS/LA (SIESTA, ANSTROKE and GOLIATH trials), Prof. D. Campbell reported a still to be confirmed potential benefit in the outcomes for GA.

However, in the Swiss registry (1,588 patients), GA was associated with a higher disability. As stroke severity was higher in the GA group, we have to be cautious before we can say we have a definitive conclusion.

From these very different results, one could suspect that there is an important “center effect” on this topic – is one more RCT needed?

 

Blood pressure management
ASTER Trial

 

Once more, a very interesting sub-analysis from the ASTER trials was presented. This specific sub-analysis demonstrated that during mechanical thrombectomy:

  1. BP variability was associated with a worst outcomeregardless of the collateral status.
  2. Hypotension time was associated with worst outcomeonly in patients with poor collateral status.
impact of 24-hour BP on outcome

This appears to be a very interesting finding for further anesthesiologic management.

A Karolinska team studied the impact of 24-hour BP on outcome after mechanical thrombectomy in acute ischemic stroke.

In cases of successful recanalization:

SBP> 160 mmHg was associated with less mRS 0-2 and more SICH.

 

Sphenopalatine Ganglion (SPG) Stimulation

SPG Stimulation is performed to augment cerebral blood flow.

This much awaited trial was presented at ESOC on this last day of the conference and simultaneously published here in Lancet .

SPG stimulation was not shown to improve in a statistically significant way 3-month disability above expectations, but it might improve outcomes in cases of cortical involvement.

If you wonder how the device is implanted you can check that out here .

The Lancet

 

Next year, the European Stroke Organization and the World Stroke Organization will jointly organize the Stroke conference in Vienna, Austria, taking place 12-15 May 2020 – and LINNC online will be there!

Until then, stay tuned on Twitter for further updates.

 

Jildaz Caroff

 

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