Endovascular Therapy for Ischemic Stroke with Perfusion- Imaging Selection

OBJECTIVES	Test whether more advanced imaging selection, recently developed devices, and earlier intervention improve outcomes.
STUDY	Investigator-initiated, international, multicenter, prospective, randomized, openlabel, blinded-endpoint.
POPULATION	Patients receiving alteplase within 4.5h with confirmed occlusion of the internal carotid or middle cerebral artery and evidence of salvageable brain tissue and ischemic core of less than 70 ml on computed tomographic (CT) perfusion imaging.
ENDPOINTS	Coprimary outcomes were reperfusion at 24 hours and early neurologic improvement (≥8-point reduction on the National Institutes of Health Stroke Scale or a score of 0 or 1 at day 3). Secondary outcomes included the functional score on the modified Rankin scale at 90 days.

Endovascular Therapy for Ischemic Stroke with Perfusion- Imaging Selection - EXTEND-IA