INR TRIALS BOOK: TABLE OF CONTENT

I. ISCHEMIC STROKE

1. Endovascular Therapies for Ischemic Stroke before 2015

• Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism
• Intra-arterial or intravenous thrombolysis for acute ischemic stroke? The SYNTHESIS pilot trial
• Solitaire flow restoration device versus the Merci Retriever in patients with acute ischemic stroke (SWIFT): a randomized, parallel-group, non-inferiority trial
• Trevo versus Merci retrievers for thrombectomy revascularization of large vessel occlusions in acute ischemic stroke (TREVO 2): a randomized trial
• A Trial of Imaging Selection and Endovascular Treatment for Ischemic Stroke - MR RESCUE
• Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke - IMS III

2. Mechanical Thrombectomy for Acute Ischemic Stroke

• A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke - MR CLEAN
• Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke - SWIFT PRIME
• Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke - ESCAPE
• Thrombectomy within 8 Hours after Symptom Onset in Ischemic Stroke - REVASCAT
• Endovascular Therapy for Ischemic Stroke with Perfusion- Imaging Selection - EXTEND-IA
• Thrombectomy in patients ineligible for iv tPA - THRILL
• Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials - HERMES collaboration meta-analysis
• Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomized controlled trial
• Endovascular therapy for acute ischemic stroke: the Pragmatic Ischemic Stroke Thrombectomy Evaluation (PISTE) randomized, controlled trial
• Thrombectomy for Stroke in the Public Health Care System of Brazil - RESILIENT

3. Thrombectomy in the Late Window

• Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct - DAWN
• Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging - DEFUSE 3
• Multicenter Randomized Clinical Trial Of Endovascular Treatment Of Acute Ischemic Stroke In The Netherlands For Late Arrivals. MR CLEAN-LATE
• The CT for Late Endovascular Reperfusion study. CLEAR

4. Device or Technique Related Trials

• Effect of Endovascular Contact Aspiration vs Stent Retriever on Revascularization in Patients With Acute Ischemic Stroke and Large Vessel Occlusion - The ASTER Randomized Clinical Trial
• Safety and Efficacy of a 3-Dimensional Stent Retriever With Aspiration- Based Thrombectomy vs Aspiration-Based Thrombectomy Alone in Acute Ischemic Stroke Intervention – A Randomized Clinical Trial (Penumbra SEPARATOR 3D)
• RECO Flow Restoration Device Versus Solitaire FR With the Intention for Thrombectomy Study (REDIRECT): a prospective randomized controlled trial

5. Mechanical Thrombectomy Alone vs Thrombectomy with IV Thrombolysis

• Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke - DIRECT MT
• Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomized controlled trial
• Effect of Mechanical Thrombectomy Without vs With Intravenous Thrombolysis on Functional Outcome Among Patients With Acute Ischemic Stroke - DIRECT-MT-SKIP
• Effect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke - DIRECT-MT-DEVT
• Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands–NO IV. MR CLEAN–NO IV
• Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4.5 h of stroke onset: an open-label, blinded-endpoint, randomized non-inferiority trial. SWIFT DIRECT
• The Chemical Optimization of Cerebral Embolectomy trial. CHOICE

6. Basilar Artery Occlusion

• Endovascular Therapy for Stroke Due to Basilar Artery Occlusion. BASICS
• Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomized controlled trial.
• Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar Artery Occlusion. BAOCHE (Basilar Artery Occlusion Chinese Endovascular trial)
• Endovascular Treatment for Acute Basilar-Artery Occlusion. ATTENTION
• Summary of characteristics and endpoints of Basilar Artery Occlusion Randomized Controlled Trials

7. M2 Segment Occlusion

• Efficacy of endovascular thrombectomy in patients with M2 segment middle cerebral artery occlusions: meta-analysis of data from the HERMES Collaboration - HERMES collaboration meta-analysis on M2 occlusion

8. Thrombectomy in Large Core Stroke (Low ASPECTS)

• The Recovery by Endovascular Salvage for Cerebral Ultra-Acute Embolism–Japan Large Ischemic Core Trial. RESCUE-JAPAN Limit
• Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients with a Large Infarct Core. ANGEL-ASPECT
• Randomized Controlled Trial to Optimize Patient’s Selection for Endovascular Treatment in Acute Ischemic Stroke. SELECT2

9. Anesthesia During Thrombectomy: General Anesthesia (GA) vs. Conscious Sedation (CS)

• Effect of Conscious Sedation vs General Anesthesia on Early Neurological Improvement Among Patients With Ischemic Stroke Undergoing Endovascular Thrombectomy A Randomized Clinical Trial - SIESTA
• General Anesthesia Versus Conscious Sedation for Endovascular Treatment of Acute Ischemic Stroke: The AnStroke (Anesthesia During Stroke) Trial
• Effect of General Anesthesia and Conscious Sedation During Endovascular Therapy on Infarct Growth and Clinical Outcomes in Acute Ischemic Stroke: A Randomized Clinical Trial - GOLIATH
• General Anesthesia versus Sedation for Acute Stroke Treatment. GASS
• Anesthesia Management in Endovascular Therapy for Ischemic Stroke. AMETIS

10. Associated Medications

• Determining the optimal dose of tenecteplase before endovascular therapy for ischemic stroke (EXTEND-IA TNK Part 1): A multicenter, randomized, controlled study
• Determining the optimal dose of tenecteplase before endovascular therapy for ischemic stroke (EXTEND-IA TNK Part 2): A multicenter, randomized, controlled study
• Efficacy and safety of nerinetide for the treatment of acute ischemic stroke (ESCAPE-NA1): a multicenter, double-blind, randomized controlled trial
• Final Results of the RHAPSODY Trial: Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator

11. Systems of Care

• Direct to Angiography Suite Without Stopping for Computed Tomography Imaging for Patients With Acute Stroke. ANGIOCAT
• Transfer to the Closest Local Stroke Center vs. Direct Transfer to Endovascular Stroke Center of Acute Stroke Patients With Suspected Large Vessel Occlusion in the Catalan Territory. RACECAT

12. Intracranial Atherosclerosis

• Effect of Stenting Plus Medical Therapy vs. Medical Therapy Alone on Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis. CASSISS

13. Carotid Disease

• Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicenter, randomized controlled trial. SPACE-2

II. HEMORRHAGIC STROKE

14. Treatment of Intracranial Cerebral Aneurysms

• Prospective Study On Embolization Of Intracranial Aneurysms With The Pipeline Device. PREMIER (1-year results)
• Prospective Study On Embolization Of Intracranial Aneurysms With The Pipeline Device. PREMIER (1-year analysis - Predictors of incomplete occlusion)
• Prospective Study On Embolization Of Intracranial Aneurysms With The Pipeline Device. PREMIER (3-year results with the application of a flow diverter specific occlusion classification)
• Safety and efficacy results of the Flow Redirection Endoluminal Device (FRED) stent system in the treatment of intracranial aneurysms: US pivotal trial. FRED
• CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS): results of 1-month and 1-year assessment of rebleeding protection and clinical safety in a multicenter study. CLARYS
• CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS). CLARYS – 12-month angiographic results
• Safety and Effectiveness of the Treatment of Wide Neck, Saccular Intracranial Aneurysms With the Neuroform Atlas Stent System Investigational Device Exemption. ATLAS IDE (Anterior Circulation)
• Safety and Effectiveness of the Treatment of Wide Neck, Saccular Intracranial Aneurysms With the Neuroform Atlas Stent System Investigational Device Exemption. ATLAS IDE (Posterior circulation)

15. Treatment of Dural Arteriovenous Fistulas

• Treatment of Dural Arteriovenous Fistulas With SQUID Liquid Embolic Agent. LIQUID

16. Treatment of Vasospasm

• Primary results of the Vesalio NeVa VS for the Treatment of Symptomatic Cerebral Vasospasm following Aneurysm Subarachnoid Hemorrhage. VITAL
• COManeci MechANical Dilation for vasospasm: multicenter experience. COMMAND registry

III. ONGOING - UNPUBLISHED - CLINICAL TRIALS

17. Ongoing - Unpublished - Clinical Trials