Literature Review

Periprocedural outcomes and early safety with the use of the Pipeline Flex Embolization Device with Shield Technology for unruptured intracranial aneurysms: preliminary results from a prospective clinical study

Selected in the Journal of NeuroInterventional Surgery by FERRAZ Fausto

Authors: Martínez-Galdámez M, Lamin SM, Lagios KG, Liebig T, Ciceri EF, Chapot R, Stockx L, Chavda S, Kabbasch C, Farago G, Nordmeyer H, Boulanger T, Piano M, Boccardi EP

Reference: J Neurointerv Surg. 2017 Aug;9(8):772-776

Published: August 2017

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Thursday 10 August 2017
Ferraz_Fausto

This prospective study analyzed the clinical outcome of 30-day post-procedure period for 50 patients/aneurysms. Mostly small aneurysms represented the cohort analysis.

Flow diverter stents have become an option for treatment for many types of unruptured intracranial aneurysms, mainly due to the good results previously presented in the literature. Shortening of procedure time and “non intrasaccular” manipulation should be considered as benefits for the indication of its use, specially for small aneurysms.

The drawback is related to the thrombogenicity, that became the goal of pipeline with Shield technology, which consists in a surface modification with a polymer coating that prevents protein adsorption-thrombin generation.

Regarding the results, there was no major stroke within the population study and only five non-severe (groin hematoma, carotid dissection, cerebral infarction, nausea) and three severe events (headache, diplopia, retroperitoneal hemorrhage) were described, all of them with no neurologic consequences.

 Mid and long-term results may confirm the technique to be the first-line treatment for small aneurysms.

 

 

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